Action Required: ShowMeVax Legacy Feed will Discontinue on January 31, 2021
The Missouri Department of Health and Senior Services reached out to vaccinators in late October and follow up calls since with an invitation to interface with the enhanced ShowMeVax, Missouri’s Immunization Information System. If you have not taken steps to continue exchanging vaccination data, be advised that the current legacy ShowMeVax feed will discontinue on January 31, 2021. Therefore, all providers wishing to continue exchanging vaccination data with the enhanced ShowMeVax will need to onboard, by registering. If you have any questions, reach out.

In February 2020, the Missouri Department of Health and Senior Services (DHSS) upgraded its Immunization Information System (IIS), ShowMeVax.  ShowMeVax was enhanced to support bi-directional interfaces and fully integrate with electronic health record systems; to meet and stay current with national immunization information standards; to operate using any current web browsers and devices; and to improve user report capabilities.

Missouri follows National Standards for Electronic Health Record (EHR) reporting.

If you are:

  • A provider/clinic who orders vaccines from the Vaccines for Children (VFC) Program or reports immunizations administered to children ages 0 through 18, you can apply for electronic data exchange with ShowMeVax.
  • A provider/clinic who does not vaccinate children ages 0 through 18 and is not mandated to report immunizations to ShowMeVax, you do not need to report to ShowMeVax.
  • A pharmacy operating in Missouri, is required to report vaccination administration to ShowMeVax as outlined in Chapter 338.010, RSMo.

Immunization reporting is one of the public health measures of the EHR Incentive Programs. If you need attestation materials or have questions about the programs, click the button above to check out our resource page.


An interface with ShowMeVax can be established for a single clinic (regardless of size) or an organization representing multiple clinics that will report through a single interface. The interface can be set up as unidirectional or bidirectional:

  • Unidirectional data is exchanged in one direction, from the EHR to the IIS. Data exchanged refers to Message Submission (VXU) and Acknowledgment (ACK).
  • Bidirectional data is exchanged in two directions, from the EHR to the IIS and from the IIS to the EHR. Data exchanged refers to Query (QBP) HL7 message submissions that are sent to an IIS and Response (RSP) HL7 message submissions that are returned by an IIS in response to a querying system.

Getting Started

Step 1 - Registration
Step 2 - Testing
Step 3 - Production


Register to start Immunization HL7 Onboarding. You will then receive step by step instructions, sent to the primary contact email, to complete the onboarding process. Read the Eligibility Requirements carefully and be sure to download and review the HL7 2.5.1 Implementation Guide and Memorandum of Agreement (MOA). Each organization must have a signed MOA on file to begin submitting data to DHSS.


Once you’re registered and ready to start submitting messages, DHSS will work with you to begin validating the structure and content of your data. Messages must meet the requirements laid out in the HL7 2.5.1 Implementation Guide.

“Real" patient immunization data (Production) will be submitted in real-time from your EHR system to the ShowMeVax QA (Test) environment to test the interface connection and message data quality. Acknowledgement (ACK) messages will be returned to your EHR system in response. You should monitor the ACKs and take action to correct submissions as needed until errors no longer occur.

  • Phase 1: Confirm that ShowMeVax can accept a test message from your EHR System.
  • Phase 2: Validate messages from your EHR that required fields are populated with proper codes.
  • Phase 3: Assess data quality of message content to ensure accurate patient data has been sent


When you’ve achieved error free messages for two weeks, DHSS will approve you to begin submitting messages to the production environment of ShowMeVax.

Once you are actively exchanging data with ShowMeVax, you must continue to review the ACK messages to ensure ongoing submission and data quality. Failed submissions or error messages should be corrected and resubmitted to ShowMeVax.