Hepatitis C Virus (HCV)

Brief Description

HCV Antibody Testing

HCV RNA Confirmatory Testing

Laboratory Unit

Virology

Immunology

Methodology

Chemiluminescent immunoassay (CLIA)

Real-time transcription-mediated amplification (TMA)

Specimen Collection

2.5ml minimum volume

SPECIMEN – Must be centrifuged within 6 hours of collection.

  • Serum (Preferred sample) – Serum separator tube.  If using a red top tube, transfer serum into secondary container.  
    Or
  • Plasma – ethylenediaminetetraacetic acid (EDTA) – Transfer plasma into secondary container.
Storage/Transport

HCV Antibody Testing

Plasma and Serum separated from the clot can be maintained at 2-8°C. Ship with freezer pillow(s) provided. Specimens must be received within seven (7) days of collection.

Plasma and Serum separated from the clot can be stored at -20°C or below and shipped with dry ice.

From collection date, Plasma and Serum Specimens samples separated from the clot must be received under one of the following conditions:

2 to 8°C within seven (7) days, or

8.1 to 30°C within four (4) days, or

-19.9 to 1.9°C within four (4) days, or

-20°C or below and shipped with dry ice.

HCV RNA Confirmatory Testing - Must be centrifuged within 6 hours of collection.

Plasma and Serum Specimens separated from the clot must be received under one of the following conditions:

0-30°C within 1 day, or

0-10°C within 3 days, or

0-8°C within 5 days, or

In a secondary tube at -20°C or below, shipped with dry ice within 60 days.

DO NOT USE ICE MADE WITH WATER WHEN SHIPPING SPECIMENS

Acceptable Specimen Type(s)

Serum
Plasma

Test Request Form(s)
Possible Results

HCV Antibody: Reactive/Non-Reactive

HCV RNA: Detected/Not Detected

Unacceptable Conditions

Hemolyzed

Lipemic

No sample ID

Improper storage/transport of specimen

Interfering Substances

Biotin concentrations greater than 100 ng/mL

Result Reported

HCV antibody screen – Day of receipt

HCV RNA – 1-4 days after receipt (performed weekly)

Fees

N/A

CPT Codes

HCV Antibody: 86803

HCV RNA: 87522

LOINC/SNOMED Codes

HCV Antibody:  13955-0

HCV RNA:  11259-9